Not all Orphan Drugs are "new" when submitted to the FDA for Orphan Drug designation and approval. Some are old drugs that were modified slightly, or not all are, but their prices increased drastically.

9Wants to Know identified 12 drugs that had been researched or used for decades prior to their being approved as "Orphan Drugs" and given market exclusivity.

Below, you can see which rare disease each of these drugs were approved to treat. Click the image to learn how much their price has increased. (Don't see the images below? Click here)